Duke quarterback Thomas Sirk reinjured his Achilles tendon and is expected to miss the 2016 season.
Sirk, a redshirt senior, aggravated the left Achilles tendon injury he suffered during offseason conditioning work in February, a source close to Duke program confirmed the News & Observer on Friday.
Sirk also missed all of the 2013 season after tearing the right Achilles.
Sirk passed for 2,625 yards and 16 touchdowns and added a team-best 803 yards rushing and eight scores last season when he led the Blue Devils to an 8-5 record.
Sirk was named the co-MVP of the Pinstripe Bowl as Duke beat Indiana 44-41 in overtime.
Head coach David Cutcliffe could turn to Parker Boehme, a redshirt junior, or Daniel Jones, a redshirt freshman, as the No. 1 quarterback.
Duke opens the season next Saturday against North Carolina Central.