McCoy, who is nursing an ailing hamstring, was limited in last Friday’s practice and didn’t fare well two days later in a 28-25 loss to the Miami Dolphins. The 28-year-old rushed eight times for 11 yards before exiting the contest in the third quarter.
McCoy performed considerably better in the first meeting with the Patriots, a 16-0 win for Buffalo on Oct. 2. He rushed for 70 yards and reeled in a season-best six catches for 38 yards and a touchdown.
McCoy has rushed 112 times for 598 yards with six touchdowns this season. He also has 20 catches for 97 yards and a score.
Wide receiver Marquise Goodwin, safety Aaron Williams, left tackle Corey Glenn and linebacker Zach Brown also missed their second practice of the week on Thursday.