- Cincinnati Bengals: Joe Burrow, QB, LSU
- Washington Redskins: Chase Young, DE, Ohio State
- Detroit Lions: Jeff Okudah, CB, Ohio State
- New York Giants: Andrew Thomas, OT, Georgia
- Miami Dolphins: Tua Tagovailoa, QB, Alabama
- L.A. Chargers: Justin Herbert, QB, Oregon
- Carolina Panthers: Derrick Brown, DT, Auburn
- Arizona Cardinals: Isaiah Simmons, OLB/NB/S/CB, Clemson
- Jacksonville Jaguars: C.J. Henderson, CB, Florida
- Cleveland Browns: Jedrick Wills Jr., OT, Alabama
- New York Jets: Mekhi Becton, OT, Louisville
- Las Vegas Raiders: Henry Ruggs III, WR, Alabama
- (Trade with San Francisco for 12th pick), Tampa Bay Buccaneers: Tristan Wirfs, OT, Iowa
- (Trade with Tampa Bay for 13th pick), San Francisco 49ers: Javon Kinlaw, DT, South Carolina
- Denver Broncos: Jerry Jeudy, WR, Alabama
- Atlanta Falcons: A.J. Terrell, CB, Clemson
- Dallas Cowboys: CeeDee Lamb, WR, Oklahoma
- Miami Dolphins: Austin Jackson, OT, USC
- Las Vegas Raiders: Damon Arnette, CB, Ohio State
- Jacksonville Jaguars: K’Lavon Chaisson, DE/OLB, LSU
- Philadelphia Eagles: Jalen Reagor, WR/KR, TCU
- Minnesota Vikings: Justin Jefferson, WR, LSU
- (Trade with New England for 22nd pick) L.A. Chargers: Kenneth Murray, LB, Oklahoma
- New Orleans Saints: Cesar Ruiz, C, Michigan
- (Trade with Minnesota for 24th pick) San Francisco 49ers: Brandon Aiyuk, WR, Arizona State
- (Trade with Miami for 26th pick) Green Bay Packers: Jordan Love, QB, Utah State
- Seattle Seahawks: Jordyn Brooks, LB, Texas Tech
- Baltimore Ravens: Patrick Queen, LB, LSU
- Tennessee Titans: Isaiah Wilson, OT, Georgia
- (Trade with Packers for 30th pick) Miami Dolphins: Noah Igbinoghene, CB, Auburn
- (Trade with 49ers for 31th pick) Minnesota Vikings: Jeff Gladney, CB, TCU
- Kansas City Chiefs: Clyde Edwards-Helaire, RB, LSU